Abstract

Abstract
In the first step, were obtained of compounds ethyl malonate and ethyl glutarate (1,2) through the reaction of di carboxylic acids (Malonic acid, Glotaric acid) with center sulfuric acid in absolute ethanol, In the second step, compounds (1,2) were converted into compounds malono hydrazide and glutaro hydrazide (3,4) through reaction of compounds (1,2) with an increase of hydrazine hydrate in concentration (80%) in absolute ethanol, as for the third step it involved converting the compounds (3,4) into two-compensation hydrazone (imines) compounds (N1,N3-benzylidene malono hydrazide) and (N1,N5-benzylidene glutaro hydrazide) (5a-d) (6a-d) through the reaction of the compounds (3,4) with different aromatic dihydes compensated in absolute ethanol, In recent step, the reaction bis-substituted hydrazone (imines) compounds (5a-d) (6a-d) with maleic, phthalic and tetra chloro phthalic anhydride in absolute ethanol produce N1,N3-bis substituted (1,3)-oxazepines, (1,3)-benzo and tetra chloro benzo oxazepines malon amid (7a-d),(9a-d),(11a-d) and N1,N5-bis substituted (1,3)-oxazepines, (1,3)-benzo and tetra chloro benzo oxazepines glutar amide (8a-d),(10a-d), (12a-d). N1,N3-bis substituted (1,3)-oxazepines, (1,3)-benzo and tetra chloro benzo oxazepines malon amide and N1,N5-bis substituted (1,3)-oxazepines, (1,3)-benzo and tetra chloro benzo oxazepines glutar amide expected to be more biologically active than usuall substituted (1,3)-oxazepines, (1,3)-benzo and tetra chloro benzo oxazepines, the compounds prepared in this study were diagnosed using spectrum (FT-IR) and the protone nuclear magnetic resonance spectrum (1H-NMR) and some physical constants.