The research aims at investigating the influence of using learning strategy based on brain on the achievement of fifth class primary school in science subject and developing their pivotal thinking skills. Experimental design with pre-post test was used. The sample consisted of (57) pupils from two primary school in Mosul city. Achievement test consisted of (26) items was used . also the researches prepared special test to measure pupils the pivotal thinking skills consisted of (19) items. By using suitable statistical procedures the results revealed that there is a significance difference between the experimental group who taught by brain strategy and control group who taught by conventional method in science achievement and pivotal thinking skills with the favor of experimental group. Some suggestions and recommendations were produced at the end of the research.