Main Subjects : Inorganic chemistry


Spectrophotometric Determination of Mesalazine by Oxidation and Shortening Using Methyl Orange Dye and Application to Pharmaceutical Preparations

Ahlam Shehab; Dawood Haboo Mohammed

College Of Basic Education Research Journal, 2021, Volume 17, Issue 4, Pages 1049-1071
DOI: 10.33899/berj.2022.170451

A rapid, sensitive and indirect spectral method was developed to estimate the mesalazine in the aqueous solution, as the method relied on the oxidation and reduction reaction of the mesalazine oxidation with an increase (calculated) from the oxidizing agent of bromate - bromide mixture in the medium of hydrochloric acid. The remaining (non-reducing) concentration then reacts. With a constant amount of methyl orange dye leads to color bleaching. The residual dye was followed at 507 nm wavelength. The relationship was linear between residual pigment absorption and increased drug concentration, and the micrographic quantities of mesalazine that followed Beer ٬ s law limits were estimated from 0.5 to 12.5 µg /ml with molar absorptivity 2.03 x 104 l.Mol-1.. cm-1 and Sand ell’s sensitivity index (0.0075357) µg / cm2 . A relative standard deviation whose value does not exceed 0.690% and the C recovery value not less than 99.05%. The method was successfully applied to the pharmaceutical preparations as tablets and it was compatible with the original content of the pharmaceuticals and with the results of the standard addition method.

دراسة حرکیة امتزاز بعض صبغاتالملونات الغذائیة باساخدام الکاربون المنشط التجاری کمادة مازة Kinetic studies for adsorption of anumber of food coloring dyes by using activated carbon

Ibrahim Yonus; خلیل النعیمی

College Of Basic Education Research Journal, 2021, Volume 17, Issue 3, Pages 1310-1335
DOI: 10.33899/berj.2021.169674

The research included the application of some kinematic models to study the adsorption process, such as the pseudo-first order (Lacquerine) and the second false (Hood and Mickey) model, the wafer kinematic model and the implicit particle diffusion model, and then applying the experimental results of the adsorption process to some food dyes through which color is given to juices, soft drinks and pastries. And foodstuffs such as jams, medicines and others that bear the following codes: E110, E122, E102, E133, E123, E124 and E127.
Commercial activated carbon was used as an adsorbent for these dyes, which constitute a very wide sector of important industries for humans everywhere in the world.
The kinematic study is indicated by obtaining important information that helps in designing a simple and economical adsorption system in order to get rid of these pigments and treat them. After using different kinematic models, the study found the applicability of the experimental results of the adsorption of colored dyes of juices, foodstuffs and soft drinks to a second-order pseudo kinetic model. Obtain the constant adsorption velocity of those pigments with good and high linear relationship and match the practical values of adsorption capacity with the theoretical values, as well as the values of the initial velocity of adsorption.

Determination of Stability Constants and Thermodynamic Parameters for Ciprofloxacin-HCl With Some Transition Metal Ions by Potentiometric Titration Technique

essam rad; Zaheda Najim

College Of Basic Education Research Journal, 2021, Volume 17, Issue 3, Pages 1368-1393
DOI: 10.33899/berj.2021.169677

This study included calculating the stability constants and stoichiometries of some binary complexes formed from the interaction of seven of metal ions (Cr+3,Mn+2,Co+2,Ni+2,Cu+2,Zn+2 and Cd+2) with Ciprofloxacin-HCl. This study was carried out using Potentiometric Titration Technique at different concentrations of the drug and the metal ion and at temperatures (288,298,310,318 and 328 K±0.1) in aqueous solution. Although, there are many methods available to study the stability of metal-ligand complexes, pH-metric is most frequently used to determine the stability constants. Hence, (Calvin - Bjerrum pH-metric titration technique) as adopted by Irving–Rossotti was used to calculate of stability constants. The results of the concentration effect study showed that the formation of complexes were more stable in dilute solutions, and through study of the temperature effect it was concluded that the stability of the complexes can be increased with raising temperature, and the stability constants value obtained were used in the calculation of thermodynamic parameters 〖(S〗^o,H,〖G〗^o). The results of this study also showed that the ciprofloxacin tends to form two types of metal complexes in the solution (ML1),(ML2) and this indicates that the reaction ratio between the drug and the metal ion was (1:1) and (1:2)(M:L) respectively for all metal ions. These ratios depended on the nature of the ligand or the metal ion, and the stability of the complexes formed increases according to the following arrangement (Mn+ 2< Co+ 2< Ni+ 2< Cu+ 2> Zn+ 2) and this arrangement is compatible with Irving Williams’s arrangement for the stability of the elements.

New Complexes of Nickel (II) with Mixed Ligands(2-oxime-4-(hydroxl benzilidine)pentane and (Thiosemicarbazones) and (Glycine) or(Metformine),Evaluation of Biological Activites and laser Irradiation

Ahlam Mohammed Yaseen Al-Bayati; Zuhoor Fathi Al-Taai

College Of Basic Education Research Journal, 2020, Volume 16, Issue 4, Pages 949-964
DOI: 10.33899/berj.2020.167245

New nickel (II) complexes with three mixed ligand {which are 2-Oxime-4 (3- hydroxyl benzlidene) pentane (L2H); 2- chloro benzaldehyde- thiosemicarbazone (T1H) or 3,4- dimethoxy aceto-phenone thiosemicarbazone (T2H); and glycine (GH) or metformin (mf)} have been prepared by applying classical and microwave heating techniques. The resulting compounds have been characterized using analytical, physical and spectral techniques. Complexes of general formulaes [Ni(L2H)(TH)(BH)](Ac)2 in slightly neutral medium and complexes of general formula [Ni(L2)(T)(mf)] and [Ni(L2)(TH)(G)] in basic medium have been resulted. {where BH= GH or mf ligand, TH= T1H or T2H ligand, L2= deprotonated L2H ligand, T= deprotonated T1H or T2H ligand, G= deprotonated GH ligand}, high spin octahedral complexes have been resulted. No laser He-Ne type (wave length are 600- 700 nm) have been observed on the compounds, this means that the compounds are stable. Biological activity of the ligands and complexes have been evaluated using agar plate diffusion technique against Echerichia coli, Klipsila pnnemoia, Staphylococcus aureus and Pseudomonas aeruginosa. Some compounds were found to have antibacterial activity.

SOME NEW ORGANOTELLURIUM COMPOUNDS DERIVED FROM 4,-4-DIHYDROXY AZOBENZENE

Thana Y. Al-Obedy

College Of Basic Education Research Journal, 2020, Volume 16, Issue 3, Pages 892-898
DOI: 10.33899/berj.2020.165715

Abstract
A new series of organotellurium compounds derived from 4,-4-dihydroxy azobenzen have been prepared by the reaction of 3-HgC1-4-OH-C6H3N=NC6H4-OH (A) with TeBr4 and P-CH3OC6H4TeBr3 to give (3-(P-CH3OC6H4TeBr2)-4-OHC6H3-N=N-C6H4-OH) (B̅) and (3-TeBr3-4-OHC6H3N=NCH4-OH) (B) respectively, reduction of B by sodium sulphide gave the corresponding organotellurenyl compound (C), (3-TeBr-4-OH-CH3N=N-C6H4-OH). Compound (D) (OH-C6H4-N=N-CH3-4-OH-3Te)2 has been prepared by reduction of compound B or C by hydrazine hydrate. Reduction of B̅ gave the corresponding telluride 3-(P-CH3OCH4Te)-4-OH-CH3N=N-C6H4-4-OH (E). All compounds have been characterized, by IR and 1H NMR spectral data and meting point was determined. The molar conductivities of the halogenated compounds (B, B̅,C) in DMSO and DMF show some weak electrolytic behavior.
Abstract
A new series of organotellurium compounds derived from 4,-4-dihydroxy azobenzen have been prepared by the reaction of 3-HgC1-4-OH-C6H3N=NC6H4-OH (A) with TeBr4 and P-CH3OC6H4TeBr3 to give (3-(P-CH3OC6H4TeBr2)-4-OHC6H3-N=N-C6H4-OH) (B̅) and (3-TeBr3-4-OHC6H3N=NCH4-OH) (B) respectively, reduction of B by sodium sulphide gave the corresponding organotellurenyl compound (C), (3-TeBr-4-OH-CH3N=N-C6H4-OH). Compound (D) (OH-C6H4-N=N-CH3-4-OH-3Te)2 has been prepared by reduction of compound B or C by hydrazine hydrate. Reduction of B̅ gave the corresponding telluride 3-(P-CH3OCH4Te)-4-OH-CH3N=N-C6H4-4-OH (E). All compounds have been characterized, by IR and 1H NMR spectral data and meting point was determined. The molar conductivities of the halogenated compounds (B, B̅,C) in DMSO and DMF show some weak electrolytic behavior.